The existence of sex chromosomes determines the gender of humans from the moment a fertilized egg is formed. Apart from male and female, are there other genders in humans? There is a type of women whose height often does not exceed 152 cm, with underdeveloped ovaries. Approximately 35% of them suffer from cardiovascular diseases, and aortic stenosis is also a common symptom, due to their chromosome composition of 22Ⅱ+X0, which lacks an X chromosome. There is also a type of women who appear normal on the surface but are considered "super-females". About two-thirds of these "super-females" have slightly lower intelligence and tendencies towards mental illness. Their sexual function, reproductive ability, and physical characteristics are all normal. Their chromosome composition is 22Ⅱ+XXX, which includes an extra X chromosome compared to normal women.
There are also diseases caused by an imbalance in sex chromosomes in men. Men with a chromosome composition of 22Ⅱ+XXY have an extra X chromosome, resulting in small testes and no sperm. Approximately 25% of them have developed breasts and resemble eunuchs in Chinese feudal society. Having too many Y chromosomes is also problematic. Men with 22Ⅱ+XYY are called "super-males". These men are tall, have high intelligence, and are stubborn in temperament. They often end up in prison due to their violent temper and anti-social behavior. Their reproductive organs are underdeveloped, with undescended testes and hypospadias, and their reproductive ability is weakened. There is also a type of man who has no X chromosomes but two Y chromosomes, forming a chromosome composition of 22Ⅱ+YY. Although they are tall, their reproductive organs are underdeveloped and their intellectual development is stunted.

